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Endogenous coccidioidal endophthalmitis

M S Blumenkranz, D A Stevens

    Ophthalmology
    |October 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Ocular involvement in coccidioidomycosis, a fungal infection, is more common than previously thought, especially in severe cases. Prompt eye exams are crucial for patients with chronic pulmonary or disseminated coccidioidomycosis.

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    Area of Science:

    • Ophthalmology
    • Infectious Diseases
    • Mycology

    Background:

    • Coccidioidomycosis typically presents as a self-limited respiratory illness.
    • Ocular involvement is considered rare, usually affecting the anterior segment and adnexa.

    Observation:

    • This prospective study examined ten patients with chronic pulmonary and disseminated coccidioidomycosis undergoing chemotherapy.
    • Four patients showed evidence of posterior segment coccidioidal dissemination.
    • One patient developed a coccidioidal lid granuloma.

    Findings:

    • Juxtapapillary choroiditis was observed in three patients.
    • One patient exhibited retinal infiltrates, telangiectatic capillary changes, and macular edema.
    • Correlation between intraocular and systemic outcomes was poor.

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  • Systemic amphotericin B showed greater efficacy than miconazole for intraocular disease.

    • Implications:

    • Intraocular involvement in progressive coccidioidomycosis may be more prevalent than previously documented.
    • Regular ophthalmological examinations are recommended for patients with chronic or disseminated coccidioidomycosis.
    • Early detection and treatment of ocular complications are vital for managing this systemic fungal infection.