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T lymphocyte mobility: defects and effects of ascorbic acid, histamine and complexed IgG
Clinical and Experimental Immunology
|January 1, 1981
Summary
Neutrophil and T lymphocyte mobility are linked, with histamine and ascorbic acid affecting T cell movement. Complexed IgG challenges prior findings on T gamma cell motility.
Area of Science:
- Immunology
- Cell Biology
- Hematology
Background:
- T lymphocyte mobility is crucial for immune responses.
- Defective lymphocyte mobility is observed in certain patient populations.
- Previous studies suggested T gamma cells do not exhibit motility.
Purpose of the Study:
- To investigate the relationship between neutrophil and T lymphocyte mobility.
- To assess the effects of histamine and ascorbic acid on T lymphocyte motility.
- To re-evaluate the motility of T gamma cells.
Main Methods:
- Comparative analysis of T lymphocyte and neutrophil mobility in healthy subjects and patients.
- Assessment of T lymphocyte and thymocyte mobility.
- Treatment with histamine and ascorbic acid to observe effects on mobility.
- Inhibition of T- or Tmu-depleted T lymphocytes using complexed IgG.
Main Results:
- Low T lymphocyte mobility correlated with low neutrophil mobility.
- Thymocytes exhibited mobility comparable to mature T lymphocytes.
- Histamine enhanced T lymphocyte mobility across all groups (healthy, patients, thymocytes).
- Ascorbic acid increased mobility in healthy subjects and thymocytes.
- Complexed IgG inhibited mobility in T- or Tmu-depleted T lymphocytes.
Conclusions:
- T lymphocyte and neutrophil mobility are interconnected.
- Histamine and ascorbic acid show potential to modulate T lymphocyte motility.
- The study provides evidence challenging the notion that T gamma cells are immobile.