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Cell mediated immune response in human cases of rhinosporidiosis
Abstract:
Leukocyte migration inhibition (LMI) and T lymphocyte counts were used as measures of cell mediated immunity in 37 patients with rhinosporidiosis and 18 healthy individuals. LMI was higher in all the patients than the normal controls, and it was maximal in patients with infection of 3-9 years' duration. When the chronicity of infection exceeded 10 years, there was a fall in LMI response although it was still more than that of the normal controls. The T cell count was significantly low with infection of 1-2 years' duration than in normals, but it rose to normal values in patients with infection that had lasted 3 years or more.
Insights
Cell mediated immunity in rhinosporidiosis patients shows altered leukocyte migration inhibition (LMI) and T lymphocyte counts. LMI peaks with 3-9 years of infection, while T cell counts normalize after 3 years.
Area of Science:
- Immunology
- Infectious Diseases
- Cell Biology
Background:
- Rhinosporidiosis is a chronic granulomatous disease affecting mucosal surfaces.
- Cell mediated immunity plays a crucial role in the host response to fungal infections like rhinosporidiosis.
Purpose of the Study:
- To evaluate cell mediated immunity in rhinosporidiosis patients using leukocyte migration inhibition (LMI) and T lymphocyte counts.
- To correlate immune responses with the duration of rhinosporidiosis infection.
Main Methods:
- Assessed leukocyte migration inhibition (LMI) in 37 rhinosporidiosis patients and 18 healthy controls.
- Measured T lymphocyte counts in patients and controls.
- Analyzed immune responses based on infection duration (1-2 years, 3-9 years, >10 years).
Main Results:
- Leukocyte migration inhibition (LMI) was elevated in all rhinosporidiosis patients compared to controls.
- LMI response peaked in patients with 3-9 years of infection duration.
- T lymphocyte counts were significantly reduced in patients with 1-2 years of infection but normalized in those with longer durations (>3 years).
Conclusions:
- Cell mediated immunity, assessed by LMI and T cell counts, is altered in rhinosporidiosis.
- The duration of infection influences the pattern of immune response in rhinosporidiosis.
- Immune responses may change over time as rhinosporidiosis becomes chronic.