A study of some pharmacological effects of a new synthetic C-nucleoside

The effect of a new synthetic C-nucleoside (2-beta-D-lyxopyranosyl-6,6-dimethyl-4,5,6,7-tetrahydroindol-4-one) on cell differentiation and growth was studied through three kinds of experiments: a) Appearance rate of peripheral blood cells in AKR mice, b) Growth capacity of Ehrlich ascite tumor cells and c) Reappearance rate of membrane receptors on T-lymphocytes which from E-rosette aggregates with sheep red cells. This C-nucleoside produced an inhibitory effect on all the processes studied, although not so strong as with the reference drug (methotrexate).