Cardiac lesions in the frog induced by adrenaline

Adrenaline (A) causes gross lesions of the ventricular wall in frogs living both at 12 degrees and 25 degrees. At 12 degrees the sensitivity of the heart to A is higher than at 25 degrees. Single or multiple ventricular aneurysm, provided by A could not be prevented by propranolol. The resistance of the myocardium towards cyanide anoxia is lowered after A especially at 25 degrees. In preliminary experiments with noradrenaline the same cardiotoxic effects are observed.