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Related Experiment Videos

Infection does not cause reflux

G W Gross, R L Lebowitz

    AJR. American Journal of Roentgenology
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Vesicoureteric reflux (VUR) in children is not caused by urinary tract infections (UTIs). This study found VUR and UTIs are independent conditions that often occur together, suggesting VUR is a primary issue.

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    Area of Science:

    • Pediatric Urology
    • Nephrology
    • Infectious Diseases

    Background:

    • Vesicoureteric reflux (VUR) was historically viewed as secondary to distal obstruction.
    • More recently, urinary tract infection (UTI) has been hypothesized as a primary cause of VUR.
    • Current understanding suggests most VUR cases are not associated with obstruction.

    Purpose of the Study:

    • To investigate the relationship between VUR and UTI in children.
    • To determine if UTI is a causative factor for VUR.
    • To analyze the independence of VUR and UTI as clinical variables.

    Main Methods:

    • Analysis of 601 voiding cystourethrograms (VCUGs) with simultaneous urine cultures in children over 12 months.
    • Categorization of patients based on the presence or absence of VUR.

    Related Experiment Videos

  • Statistical comparison of UTI prevalence in children with and without VUR.

    • Main Results:

    • Vesicoureteric reflux was present in 34% of children (204/601).
    • Of children with VUR, 88% had sterile urine, indicating infection was not the cause.
    • Prevalence of infection in children without VUR was similar (10%), suggesting independence.

    Conclusions:

    • The study data do not support the hypothesis that VUR is secondary to UTI in children.
    • Vesicoureteric reflux and urinary tract infection appear to be independent variables that frequently coexist.
    • Vesicoureteric reflux is concluded to be a primary phenomenon, likely due to ureterovesical junction incompetence.