Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Computer-enhanced thallium scintigrams in asymptomatic men with abnormal exercise tests

G S Uhl, T N Kay, J R Hickman

    The American Journal of Cardiology
    |December 1, 1981
    PubMed
    Summary

    Computer-enhanced thallium scans accurately diagnose coronary artery disease in asymptomatic individuals with abnormal stress tests. This method improves diagnostic accuracy, aiding in patient counseling regarding heart disease risk.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The contribution of drinking water to exposure to toxic substances in Canada.

    Environmental monitoring and assessment·2013
    Same author

    Expediting publication to inform political debates.

    The New England journal of medicine·1999
    Same author

    Discrepancies in international normalized ratios (INR) in swine and humans.

    Clinical laboratory science : journal of the American Society for Medical Technology·1998
    Same author

    Primary idiopathic optic neuritis in U.S. Air Force Aviators.

    Aviation, space, and environmental medicine·1998
    Same author

    Rapid removal of platelets from plasma utilizing the Hepcheck heparin removal filter.

    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·1997
    Same author

    Peripheral blood lymphocyte apoptosis: a clue to the diagnosis of acute infectious mononucleosis.

    Archives of pathology & laboratory medicine·1996

    Area of Science:

    • Cardiology
    • Nuclear Medicine
    • Diagnostic Imaging

    Background:

    • Treadmill testing is increasingly used for asymptomatic patients, but false positive stress electrocardiograms rise with lower disease prevalence.
    • Accurate diagnosis is crucial for this subgroup to guide management and counseling.

    Purpose of the Study:

    • To evaluate the diagnostic accuracy of computer-enhanced thallium perfusion scintigraphy in asymptomatic patients with abnormal exercise electrocardiograms.
    • To assess the utility of this imaging technique in identifying coronary artery disease in a low-prevalence population.

    Main Methods:

    • 191 asymptomatic U.S. Air Force aircrewmen with abnormal exercise electrocardiograms underwent multigated thallium scans.
    • Scans were performed post-exercise and 3-4 hours later, with raw images enhanced by computer before interpretation.

    Related Experiment Videos

  • Coronary angiography was used to confirm findings, categorizing patients into normal, subcritical, or significant coronary artery disease.

    • Main Results:

    • Computer enhancement significantly improved accuracy, yielding only 4 false positives and 2 false negatives among 191 patients.
    • Thallium scintigraphy detected significant coronary artery disease in 41 patients and subcritical stenosis in 15.
    • Subcritical coronary disease showed equivocal results, highlighting its detection but unclear clinical significance.

    Conclusions:

    • Computer-enhanced thallium scintigraphy is an accurate diagnostic tool for asymptomatic individuals with abnormal maximal stress electrocardiograms.
    • This technique can be effectively utilized for counseling patients on their likelihood of having coronary artery disease.
    • Thallium scintigraphy aids in identifying coronary artery disease, even in cases of subcritical stenosis.