Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune complex-dependent T cell-mediated cytostasis (IDTC)

J Tanaka, J Yata

    Clinical and Experimental Immunology
    |July 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Specificity of androgenic regulation of input to sexually dimorphic motoneurons in male rat lumbar spinal cord.

    Experimental neurology·1995
    Same author

    Serum levels of six pancreatic enzymes as related to the degree of renal dysfunction.

    The American journal of gastroenterology·1995
    Same author

    Coronary artery reoperation through the left thoracotomy with hypothermic circulatory arrest.

    The Annals of thoracic surgery·1995
    Same author

    Possible role of T-cell surface molecule gene expression in the mixed lymphocyte culture for predicting transplantation-related complications after allogeneic bone marrow transplantation.

    European journal of haematology·1995
    Same author

    Monoethylglycinexylidide formation as an independent measure of warm hepatic ischemia and reperfusion injury.

    The Journal of surgical research·1995
    Same author

    Laparoscopic retrieval of disconnected ventriculoperitoneal shunt catheters: report of two cases.

    Surgical laparoscopy & endoscopy·1995

    Immune complexes (IC) trigger T cells with IgG receptors (TG cells) to suppress lymphoid cell growth. This immune complex-dependent T cell-mediated cytostasis (IDTC) may contribute to tissue injury, with distinct functions observed in rheumatoid arthritis patients.

    Area of Science:

    • Immunology
    • Cell Biology
    • Pathology

    Background:

    • Immune complexes (IC) play a role in various immune responses and inflammatory conditions.
    • T cells are critical components of the adaptive immune system, involved in regulating immune responses and cell-mediated cytotoxicity.
    • The interaction between T cells and IC can modulate immune cell function, but the specific mechanisms are not fully elucidated.

    Purpose of the Study:

    • To investigate the role of human peripheral T cells in suppressing lymphoid cell line growth in the presence of immune complexes (IC).
    • To identify the specific T cell subsets involved in IC-mediated cytostasis and characterize their functions.
    • To propose a new term, 'immune complex-dependent T cell-mediated cytostasis' (IDTC), and explore its potential role in IC-mediated tissue injury.

    Main Methods:

    Related Experiment Videos

    • Co-culture of human lymphoid cell lines with human peripheral T cells in the presence of IC.
    • Characterization of T cell subsets, specifically T cells bearing IgG receptors (TG cells), T-non-G cells, and non-T cells, as effector cells.
    • Assessment of cytostatic and Ig production-suppressive functions of TG cells from healthy individuals and rheumatoid arthritis patients.

    Main Results:

    • Human peripheral T cells, particularly TG cells, suppressed the growth of lymphoid cell lines when incubated with IC.
    • IC-mediated bridging of target and effector cells via Fc receptors induced cytostasis mediated by TG cells.
    • TG cells from healthy individuals exhibited both Ig production suppression and cytotoxic effector functions upon IC interaction.
    • TG cells from rheumatoid arthritis patients demonstrated cytostasis but had impaired suppressive effects on B cell response, indicating a functional dissociation.

    Conclusions:

    • Immune complex-dependent T cell-mediated cytostasis (IDTC) is a phenomenon mediated by TG cells.
    • IDTC may contribute to IC-mediated tissue injury, particularly in conditions with T cell infiltration.
    • A functional dissociation exists between cytostatic and Ig production-suppressive functions of TG cells in rheumatoid arthritis, suggesting distinct effector mechanisms.