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Updated: Aug 12, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Perforation of the intussuscepted colon
Insights
Infants under six months with intussusception are at high risk for colon perforation during barium enema reduction. These younger, sicker infants often present with complete bowel obstruction and require surgery.
Area of Science:
- Pediatric surgery
- Gastroenterology
Background:
- Intussusception is a common surgical emergency in infants.
- Barium enema reduction is a standard treatment, but carries risks.
Purpose of the Study:
- To identify risk factors for colonic perforation during barium enema reduction for intussusception.
- To characterize the clinical presentation of infants who experience perforation.
Main Methods:
- Retrospective review of hospital records for nearly 1,000 infants and children with intussusception over 25 years.
- Analysis of outcomes for approximately 850 patients who underwent barium enema reduction.
Main Results:
- Six patients (all ≤ 6 months old) experienced colonic perforation during barium enema.
- These infants presented with severe symptoms including complete bowel obstruction, lethargy, dehydration, and prolonged illness (>36 hours).
- Perforations occurred in areas of necrotic, ischemic colon, necessitating right hemicolectomy.
Conclusions:
- Younger infants (< 6 months) with intussusception and complete bowel obstruction are at significantly increased risk for barium enema-induced colonic perforation.
- Clinical presentation of these high-risk infants includes severe illness, dehydration, and prolonged symptoms.
- Barium enema carries a substantial risk of perforation in this vulnerable pediatric population.
Abstract:
Hospital records were reviewed of almost 1,000 infants and children with intussusception during a 25 year period. Among the approximately 850 who had barium enemas, six had colonic perforations during the attempted hydrostatic barium enema reduction of the intussusception. All occurred in patients 6 months old or less. Most had preceding viral illness, four had pain, all vomited, five had rectal bleeding, and only one had a palpable mass. All were pale, dehydrated, lethargic, and had intermittent mottling of the skin and complete bowel obstruction. All had been ill for over 36 hr. The perforations occurred through areas of necrotic ischemic colon. All infants required a right hemicolectomy. These babies seem to fit a pattern in which they are younger and sicker longer than the average patient with intussusception and have complete bowel obstruction. These facts are a warning that such infants are at increased risk for a barium enema bowel perforation.
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