Immunity in migraine: the effect of heparin

There is evidence that migraine has an immunologic component. Migraine patients have reduced levels of circulating basophils and T-lymphocytes and there is a negative correlation of T-cell levels and disease activity. Clinical improvement of migraine is observed after the repeated inhalation of heparin in those patients in whom heparin raises both basophil and T-lymphocyte values to the normal range.