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Related Experiment Videos

Posterior keratoconus

J H Krachmer, M M Rodrigues

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Posterior keratoconus, a rare corneal condition, involves thinning of the cornea. Microscopic analysis reveals early developmental abnormalities in Descemet's membrane, suggesting a gestational origin.

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    Area of Science:

    • Ophthalmology
    • Corneal Diseases
    • Developmental Biology

    Background:

    • Posterior keratoconus is a rare, noninflammatory corneal disorder.
    • Characterized by posterior thinning and protrusion with a normal anterior surface.
    • Etiology and pathogenesis remain incompletely understood.

    Observation:

    • A corneal button from a patient with bilateral posterior keratoconus was examined.
    • Light and electron microscopy were utilized for detailed structural analysis.
    • Specific focus on Descemet's membrane in thinned stromal areas.

    Findings:

    • Descemet's membrane showed abnormal anterior banding.
    • A multilaminar configuration of Descemet's membrane was observed.
    • Localized posterior excrescences on Descemet's membrane were identified.

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    Implications:

    • These findings suggest an early pathogenetic mechanism for posterior keratoconus.
    • Alterations likely originate before the fifth or sixth month of gestation.
    • Provides insights into the developmental origins of corneal ectasias.