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T cells from radiation chimeras in several strain combinations cause lethal GVHD in irradiated, bone-marrow-protected mice which share the D end of the H-2 complex with the T cells and also have foreign determinants. This phenomenon was not found with T cells from normal mice. I suggest that H-2-restricted GVD cells may be present in normal mice, but their effects may be masked by unrestricted GVH cells, which however, develop more slowly in the chimeras so that lethality due to restricted cells can be observed.
T cells from radiation chimeras in several strain combinations cause lethal GVHD in irradiated, bone-marrow-protected mice which share the D end of the H-2 complex with the T cells and also have foreign determinants. This phenomenon was not found with T cells from normal mice. I suggest that H-2-restricted GVD cells may be present in normal mice, but their effects may be masked by unrestricted GVH cells, which however, develop more slowly in the chimeras so that lethality due to restricted cells can be observed.