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Behavioral model for diffuse noxious inhibitory controls (DNIC): potentiation by 5-hydroxytryptophan

E Kraus, J M Besson, D Le Bars

    Brain Research
    |January 14, 1982
    PubMed
    Summary

    The serotonin precursor 5-HTP enhances a pain-inhibiting response. This effect, known as diffuse noxious inhibitory controls (DNIC), was blocked by a 5-HT receptor antagonist, confirming serotonin's role.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Pain Research

    Background:

    • Serotonin (5-HT) is a neurotransmitter involved in various physiological processes.
    • Diffuse noxious inhibitory controls (DNIC) are a descending pain modulatory system.

    Purpose of the Study:

    • To investigate the effect of 5-hydroxytryptophan (5-HTP), a serotonin precursor, on the DNIC phenomenon.
    • To determine the role of serotonin receptors in 5-HTP-mediated DNIC potentiation.

    Main Methods:

    • Behavioral DNIC paradigm involving vocalization threshold measurement.
    • Intraperitoneal injection of phenylbenzoquinone (algogenic agent).
    • Administration of 5-HTP and the 5-HT receptor blocker, cinanserin.

    Main Results:

    Related Experiment Videos

    • 5-HTP significantly potentiated the DNIC phenomenon.
    • The potentiating effect of 5-HTP was completely blocked by cinanserin.
    • Results align with previous single-unit recordings in dorsal horn neurons.

    Conclusions:

    • Serotonin, via its precursor 5-HTP, plays a significant role in modulating pain through the DNIC pathway.
    • 5-HT receptors are crucial for this serotonin-mediated antinociception.