Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Normal distribution of factor B (Bf) allotypes in multiple sclerosis

J Bertrams, H Grosse-Wilde, E K Kuwert

Journal of Neuroimmunology

|March 1, 1981

Summary

This study found no significant differences in Bf allotypes between multiple sclerosis (MS) patients and controls. Bf allotype frequencies remained normal even in MS patients with specific HLA markers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Soluble HLA-G is an independent factor for the prediction of pregnancy outcome after ART: a German multi-centre study.

Human reproduction (Oxford, England)·2010

Same author

The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia.

Leukemia·2010

Same author

TNF-alpha and IL-10 gene polymorphisms show a weak association with pemphigus vulgaris in the Slovak population.

Journal of the European Academy of Dermatology and Venereology : JEADV·2009

Same author

14th International HLA and Immunogenetics Workshop Prospective Chronic Rejection Project: a three-year follow-up analysis.

Clinical transplants·2008

Same author

Prevalence of latent tuberculosis infection in German radiologists.

The Journal of hospital infection·2008

Same author

Detection of chromium allergy by cellular in vitro methods.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2008

Area of Science:

Immunogenetics
Neurology
Human Genetics

Background:

The complement system's Factor B (Bf) allotypes are studied for their potential association with autoimmune diseases.
Multiple Sclerosis (MS) is a complex neurological disorder with a suspected immune component.
Previous research has explored genetic factors, including HLA associations, in MS pathogenesis.

Purpose of the Study:

To investigate the distribution of Bf allotypes in a cohort of multiple sclerosis patients.
To compare Bf allotype frequencies in MS patients against a control population.
To examine Bf allotype frequencies in relation to specific HLA markers (HLA-B7 and HLA-Dw2) within the MS group.

Main Methods:

Blood samples were collected from 200 individuals diagnosed with multiple sclerosis.
Bf allotyping was performed using established serological or molecular techniques.
Phenotypic frequencies of Bf allotypes in the MS cohort were statistically compared to those of a control group.
Subgroup analysis was conducted for MS patients positive for HLA-B7 and/or HLA-Dw2.

Main Results:

No statistically significant deviations in the frequencies of any Bf allotypes were observed between multiple sclerosis patients and the control group.
The distribution of Bf allotypes was found to be normal across the entire MS patient cohort.
MS patients carrying HLA-B7 and/or HLA-Dw2 markers also exhibited normal Bf allotype frequencies, with no significant associations noted.

Conclusions:

The findings suggest that Bf allotypes are unlikely to be major genetic risk factors for multiple sclerosis.
The study does not support a direct link between specific Bf allotypes and MS susceptibility, even in the presence of known HLA risk factors.
Further research may explore other complement system components or genetic interactions in MS etiology.

Related Experiment Videos