Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Issues in immunologically-mediated hepatic injury

T S Edgington, I R Mackay

    The Medical Journal of Australia
    |November 28, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Levels of BAFF in serum in primary biliary cirrhosis and autoimmune diabetes.

    Autoimmunity·2003
    Same author

    Humanism and the suffering of the people.

    Internal medicine journal·2003
    Same author

    Autoantibodies to the islet cell antigen SOX-13 are associated with duration but not type of diabetes.

    Diabetic medicine : a journal of the British Diabetic Association·2003
    Same author

    A dietary cause of type 1 diabetes: unearthing a new twist to the tale.

    Diabetes technology & therapeutics·2002
    Same author

    Antimitochondrial autoantibodies in saliva and sera from patients with primary biliary cirrhosis.

    Journal of gastroenterology and hepatology·2002
    Same author

    Dietary microbial toxins and type 1 diabetes--a new meaning for seed and soil.

    Diabetologia·2001

    Chronic hepatitis involves immune responses that can harm the host. Research is needed to understand how immune cells and antibodies contribute to liver damage and viral persistence.

    Area of Science:

    • Immunology
    • Hepatology
    • Virology

    Background:

    • Chronic hepatitis B virus infection is a global health concern.
    • Pathogenic host immune responses contribute to chronic hepatitis.
    • Immune effector mechanisms in chronic hepatitis require further investigation.

    Purpose of the Study:

    • To assess faulty immune effector mechanisms in chronic hepatitis.
    • To review immune pathways involved in hepatocyte killing.
    • To explore the role of antibodies in modulating immune responses.

    Main Methods:

    • Conference study group report.
    • Assessment of immune effector cell recruitment and cytolytic mechanisms.
    • Consideration of T lymphocytes, K cells, NK cells, macrophages, and antibody-complement systems.

    Related Experiment Videos

    Main Results:

    • Evidence for specific immune effector processes in human chronic hepatitis remains unconvincing.
    • Surface-located antibodies may reduce T cell-mediated killing of infected hepatocytes, potentially facilitating chronicity.
    • Current understanding of immune mechanisms in chronic hepatitis is incomplete.

    Conclusions:

    • Future research should define cytolytic effector systems and their specificity.
    • Investigating the circumstances under which antibodies modulate immune activity is crucial.
    • Developing suitable animal models is necessary for further study.