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Related Experiment Videos

T cell leukemia presenting as chronic polyarthritis

R M van Soesbergen, T M Feltkamp-Vroom, C A Feltkamp

    Arthritis and Rheumatism
    |January 1, 1982
    PubMed
    Summary
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    A woman with chronic polyarthritis was diagnosed with T cell leukemia. The leukemic T cells exhibited characteristics of immature T cells, suggesting a malignant transformation.

    Area of Science:

    • Hematology
    • Immunology
    • Oncology

    Background:

    • Chronic polyarthritis can be associated with various systemic conditions.
    • T cell leukemia is a malignancy of T lymphocytes, often presenting with diverse clinical manifestations.

    Observation:

    • A patient with chronic polyarthritis presented with elevated peripheral blood leukocytes, predominantly T lymphocytes (95%).
    • T cell infiltration was observed in bone marrow, synovial fluid, tissue, and rheumatoid nodule-like skin lesions.
    • Microscopic examination revealed T cells with irregular nuclei, specific enzyme activity patterns, and abnormal cell surface glycopeptides.

    Findings:

    • Leukemic T cells demonstrated negative Ia-like antigen and surface immunoglobulin.
    • Enzyme chemistry and cytochemistry showed absent alpha-naphthyl acetate esterase and faint acid-phosphatase activity.

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  • Abnormally enlarged carbohydrate structures were detected on the cell surface glycopeptides.

    • Implications:

    • The findings suggest the leukemic T cells represent a malignant counterpart of immature T cells.
    • This case highlights a potential link between chronic polyarthritis and T cell leukemia of immature T cell origin.
    • Further research may elucidate the pathogenesis and therapeutic strategies for such rare T cell malignancies.