IgG antinuclear antibody dynamics between mothers and fetuses (study mainly in terms of IgG antinuclear antibody in...

Almost one fourth century has passed since the existence of antinuclear antibody (antinuclear factor) which participates in autoimmune disease was known. In the present study, the author considered antinuclear antibody (ANF)from a stand as a obstetrician. In such a case, -especially when considering the relationship between mother's physical conditions and the fetus-, it seems to be the most reasonable to investigate the dynamics of transplacental Immunoglobulin G of antinuclear antibody (IgG ANF), and, consequently, the author selected randomly 60 subjects hospitalized in Department of Obstetrics and Gynecology, Fussa Hospital, and the antibody units of IgG ANF in serum of mothers were measured at the delivery and in the puerperal stage (one month after delivery) and those of babies were measured at the birth. On the basis of these measured values, studies were made from various viewpoints. From the obtained results, the author had impression that, although the newborns from the mothers having always higher antibody units of IgG ANF presented no abnormalities in physical examinations, they were more susceptible to reduction in vitality for about 3 weeks following their birth, and that the birth of boys tended to be more often among such mothers.