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Beclomethasone dipropionate aerosol: hematologic and immunologic effects

M S Blaiss, H G Herrod, L V Crawford

    Annals of Allergy
    |April 1, 1982
    PubMed
    Summary

    Inhaled beclomethasone dipropionate aerosol, a corticosteroid for asthma, can affect circulating leukocytes in healthy adults. Studies show it may increase white blood cell and neutrophil counts, with potential impacts on other immune cells.

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    Area of Science:

    • Immunology
    • Pharmacology
    • Respiratory Medicine

    Background:

    • Inhaled beclomethasone dipropionate aerosol is a key treatment for asthma.
    • Its effects on circulating leukocytes and immune markers in healthy individuals require investigation.

    Purpose of the Study:

    • To evaluate the impact of inhaled beclomethasone dipropionate aerosol on circulating leukocytes and immunological measurements in normal adult subjects.
    • To assess dose-dependent effects and changes following single and repeated inhalations.

    Main Methods:

    • Healthy adult subjects inhaled single doses of 400 or 1600 micrograms of beclomethasone dipropionate aerosol.
    • A separate group inhaled 200 micrograms four times daily for 24 hours.
    • Blood samples were analyzed for white blood cell counts, neutrophil, eosinophil, lymphocyte counts, T and B cell numbers, and lymphocyte transformation.

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    Main Results:

    • A single 400 microgram dose significantly increased total white blood cell and neutrophil counts at six hours post-inhalation.
    • Similar trends were observed with a 1600 microgram dose, though not all changes reached statistical significance.
    • Repeated, lower-dose inhalations showed similar trends but without statistically significant changes in immunological markers.

    Conclusions:

    • Inhaled beclomethasone dipropionate aerosol demonstrates the potential to modulate circulating leukocyte populations in healthy adults.
    • The study indicates a possible, though not always statistically significant, impact on immune cell counts following both single high-dose and repeated lower-dose administrations.