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[Sex differences in the effect of acylhydrazines on temperature and pain threshold and in pharmacokinetics and tissue
Farmakologiia I Toksikologiia
|March 1, 1982
Abstract:
It was shown that acylhydrazines derivatives display high sex selectivity during the action on normal or elevated temperature and pain threshold. Tissue distribution and the pharmacokinetics of 125I- or 131-I-p-aminobenzhydrazide in the blood of males and females were different. It is assumed that essential differences in the structure of cell membranes of males and females underlie the sex differences in the pharmacological effects of acylhydrazines.