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Immune responses and immunostimulation in tuberculosis therapy

E M Gatner, R Anderson

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |May 8, 1982
    PubMed
    Summary

    This study found no specific immune deficiency predisposing individuals to tuberculosis (TB). Immunostimulants may benefit non-reactive TB patients, but their targets remain uncertain.

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    Area of Science:

    • Immunology
    • Infectious Diseases
    • Microbiology

    Background:

    • Extensive research exists on immune responses in tuberculosis.
    • Immune abnormalities in TB are typically secondary, not primary causes.
    • No specific immune deficiency explains progression from infection to disease.

    Purpose of the Study:

    • To review the role of immune responses in tuberculosis.
    • To evaluate the potential use of immunostimulants in TB therapy.
    • To identify patient subgroups that might benefit from immunostimulants.

    Main Methods:

    • Literature review of cellular and humoral immune responses in tuberculosis.
    • Analysis of evidence for TB occurring on a spectrum.
    • Discussion of the current understanding of immunostimulant mechanisms and targets.

    Main Results:

    • No discrete immune deficiency identified as predisposing to tuberculosis.
    • Tuberculosis disease spectrum suggested, analogous to leprosy.
    • Current immunostimulants lack specific targets in tuberculosis.

    Conclusions:

    • Immune responses in tuberculosis are generally secondary to the disease.
    • Immunostimulants, if used, should target non-reactive tuberculosis patients.
    • The indiscriminate action and uncertain targets of immunostimulants limit their therapeutic role.

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