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[Histamine in rheumatic diseases]

G Partsch, W Schwägerl, R Eberl

    Zeitschrift Fur Rheumatologie
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Histamine levels were measured in patients with rheumatic diseases. Higher histamine frequency was observed in rheumatoid arthritis patient serum compared to controls.

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    Area of Science:

    • Biochemistry
    • Immunology
    • Rheumatology

    Context:

    • Rheumatic diseases encompass a range of inflammatory conditions affecting joints and connective tissues.
    • Histamine, a biogenic amine, plays a role in inflammatory processes.
    • Understanding histamine's role in rheumatic diseases can provide insights into disease mechanisms.

    Purpose:

    • To quantify histamine levels in various biological samples from patients with rheumatic diseases.
    • To compare histamine concentrations in patients with rheumatoid arthritis versus healthy controls.
    • To investigate the presence and levels of histamine in synovial fluid and tissue.

    Summary:

    • Histamine was quantified in serum, leucocytes, synovial fluid, and synovial tissue of patients with rheumatic diseases.

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  • Serum histamine was more frequent in rheumatoid arthritis patients (50%) than in controls (10%).
  • Synovial fluid from rheumatoid arthritis patients contained histamine levels ranging from 1.0 to 23.4 ng/ml; leucocyte histamine levels did not differ.

    • Impact:

    • This study highlights the potential involvement of histamine in the pathophysiology of rheumatoid arthritis.
    • Findings suggest histamine may serve as a biomarker in certain rheumatic conditions.
    • Further research into histamine modulation could offer new therapeutic strategies for rheumatic diseases.