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Pharmacokinetics of potassium clavulanate in combination with amoxicillin in pediatric patients
Antimicrobial Agents and Chemotherapy
|April 1, 1982
Insights
A higher dosage of amoxicillin and potassium clavulanate liquid suspension achieved optimal plasma concentrations in pediatric patients. Lower doses proved insufficient, highlighting the importance of appropriate amoxicillin dosing.
Area of Science:
- Pediatric pharmacology
- Antibiotic pharmacokinetics
Background:
- Amoxicillin and potassium clavulanate is a common antibiotic combination.
- Optimizing pediatric dosing is crucial for effective treatment and preventing resistance.
Purpose of the Study:
- To evaluate the pharmacokinetic profile of two different dosages of amoxicillin and potassium clavulanate suspension in pediatric patients.
- To determine the optimal dosage for achieving therapeutic plasma concentrations.
Main Methods:
- A study involving 34 infants and children.
- Administration of two distinct dosages of a liquid suspension formulation.
- Measurement of plasma concentrations of amoxicillin and clavulanic acid.
Main Results:
- The lower dosage resulted in suboptimal plasma concentrations.
- The higher dosage (3.3 mg clavulanate/kg, 13.3 mg amoxicillin/kg) yielded mean peak plasma concentrations of 1.6 µg/mL for clavulanic acid and 4.9 µg/mL for amoxicillin.
- These concentrations suggest therapeutic efficacy.
Conclusions:
- The higher dosage regimen is recommended for achieving adequate therapeutic drug levels in pediatric populations.
- Accurate dosing of amoxicillin and potassium clavulanate is essential for effective pediatric antibiotic therapy.
Abstract:
Two dosages of a liquid suspension formulation of amoxicillin and potassium clavulanate were tested in 34 infants and children. The smaller dosage resulted in suboptimal plasma concentrations. With a greater dosage (3.3 mg of clavulanate per kg and 13.3 mg of amoxicillin per kg), the mean peak plasma concentrations were 1.6 micrograms clavulanic acid per ml and 4.9 micrograms amoxicillin per ml.