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[Pathomorphosis of rheumatic diseases]

I M Kodolova, T N Kop'eva, L V Kakturskiĭ

    Arkhiv Patologii
    |January 1, 1982
    PubMed
    Summary

    Immunosuppressive and anti-inflammatory therapies alter rheumatic disease presentation. Rheumatic fever shows milder symptoms, while systemic lupus erythematosus and rheumatoid arthritis exhibit improved clinical and morphological outcomes due to treatment.

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    Area of Science:

    • Rheumatology
    • Pathology
    • Immunology

    Context:

    • Investigates the impact of immunosuppressive and anti-inflammatory therapies on rheumatic diseases.
    • Analyzes clinico-anatomic data from skin, kidney, synovial, and lung tissues.

    Purpose:

    • To understand how medical interventions modify the clinical course and tissue-level changes in rheumatic conditions.
    • To document pathomorphosis in rheumatic fever, systemic lupus erythematosus, and rheumatoid arthritis.

    Summary:

    • Rheumatic fever cases displayed reduced vasculitis and myocardial impact, with a shift in mortality towards middle age, indicating epidemiological changes and pathomorphosis.
    • Systemic lupus erythematosus and rheumatoid arthritis showed positive responses to treatment, affecting clinical, morphological, and immunological aspects, signifying partial pathomorphosis.

    Impact:

    • Highlights the evolving nature of rheumatic diseases under therapeutic pressure.
    • Suggests that treatment can induce favorable changes in disease manifestation and progression.
    • Provides insights into the pathomorphosis of significant rheumatic conditions, informing future research and clinical practice.

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