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Meesmann's corneal dystrophy: ultrastructural features

M Tremblay, I Dubé

    Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Meesmann

    Area of Science:

    • Ophthalmology
    • Cell Biology
    • Histology

    Background:

    • Meesmann's corneal dystrophy is a rare genetic eye disorder.
    • Characterized by epithelial cysts and basement membrane thickening.
    • Ultrastructural analysis is crucial for understanding disease mechanisms.

    Purpose of the Study:

    • To investigate the ultrastructural features of Meesmann's corneal dystrophy.
    • To elucidate the cellular basis of cyst formation and basement membrane changes.

    Main Methods:

    • Lamellar keratoplasty tissue analysis.
    • Light microscopy and electron microscopy.
    • Histochemical staining (PAS, Hale's colloidal iron).

    Main Results:

    Related Experiment Videos

  • Epithelial cysts with corrugated walls (acantholysis) observed.
  • Epithelial cells rich in glycogen and containing a unique substance linked to tonofilaments and desmosomes.
  • Markedly thickened basement membrane with collagen fibrils and fibroblasts, suggesting repair.

    • Conclusions:

    • Ultrastructural findings confirm acantholysis and glycogen accumulation in Meesmann's corneal dystrophy.
    • Basement membrane thickening involves collagen deposition and fibroblast activity, possibly a reparative response.
    • Provides detailed insights into the pathogenesis of this corneal dystrophy.