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Human T-cell function in experimental ascorbic acid deficiency and spontaneous scurvy

N E Kay, D E Holloway, S W Hutton

    The American Journal of Clinical Nutrition
    |July 1, 1982
    PubMed
    Summary
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    Vitamin C deficiency (ascorbic acid deficiency) in humans, even at scorbutic levels, does not impact T-cell numbers or function. This study found no impairment in T-cell immunity despite low ascorbic acid levels.

    Area of Science:

    • Human physiology
    • Immunology
    • Nutritional science

    Background:

    • Animal studies suggest ascorbic acid deficiency impairs T-cell immunity.
    • The effect of ascorbic acid deficiency on human T-cell function remains unclear.

    Purpose of the Study:

    • To investigate the impact of ascorbic acid deficiency on T-cell parameters in humans.
    • To determine if severe ascorbic acid deficiency affects T-cell numbers or function.

    Main Methods:

    • Five healthy volunteers underwent controlled dietary depletion of ascorbic acid.
    • Plasma and leukocyte ascorbic acid levels were measured.
    • T-cell parameters, including mitogen responsiveness and T-cell subset percentages, were assessed.

    Main Results:

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    • Ascorbic acid levels in plasma and leukocytes decreased significantly, reaching levels found in scurvy.
    • No significant differences were observed in T-cell numbers or function between ascorbic acid-sufficient and deficient periods.
    • A patient with scurvy showed no change in T-cell parameters after ascorbic acid repletion.

    Conclusions:

    • Ascorbic acid deficiency, even at scorbutic levels, does not alter T-cell numbers in humans.
    • In vitro T-cell function is not impaired by severe ascorbic acid deficiency in humans.