Related Experiment Videos
Antibiotic-associated hemorrhagic colitis
The American Journal of Gastroenterology
|July 1, 1982
Summary
Penicillin derivatives can cause hemorrhagic colitis, a condition distinct from Clostridium difficile infections. Prompt diagnosis via colonoscopy and antibiotic cessation led to rapid patient recovery.
Area of Science:
- Gastroenterology
- Colorectal Surgery
- Pathology
Background:
- Antibiotic-induced bowel injury commonly presents as Clostridium difficile-associated pseudomembranous colitis.
- The spectrum of antibiotic-related pathology includes less common forms of colitis.
Observation:
- Two cases of hemorrhagic colitis linked to penicillin derivative use were identified.
- Clinical presentation included right-sided colonic inflammation with significant hemorrhage.
- Rectal and distal colon sparing, and absence of pseudomembranes were notable features.
Findings:
- Colonoscopy revealed marked hemorrhage within the lamina propria.
- Discontinuation of the causative antibiotic agent resulted in swift clinical improvement.
- Histological and endoscopic resolution was achieved within 9 days of follow-up.
Implications:
- Penicillin derivatives represent a potential cause of hemorrhagic colitis.
- Early colonoscopic diagnosis is crucial for appropriate management.
- This condition highlights the diverse gastrointestinal effects of antibiotic therapy.