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Related Experiment Videos

Bobbing oscillopsia from gentamicin toxicity

R T Ramsden, P Ackrill

    British Journal of Audiology
    |May 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Patients with gentamicin-induced labyrinthine damage reported vertical visual bouncing when walking, not vertigo. This symptom, linked to bilateral vestibular loss, improved over months without hearing loss.

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    Area of Science:

    • Nephrology
    • Ototoxicology
    • Neurology

    Background:

    • Gentamicin, an aminoglycoside antibiotic, is known for potential ototoxicity.
    • Patients with renal failure often receive gentamicin, increasing risk.
    • Concurrent use of other ototoxic agents, like loop diuretics, exacerbates this risk.

    Purpose of the Study:

    • To investigate the specific vestibular symptoms experienced by patients with severe labyrinthine damage from gentamicin.
    • To characterize the nature and progression of these symptoms.
    • To explore potential mechanisms underlying the observed phenomenon.

    Main Methods:

    • Study included 15 patients with renal failure and severe labyrinthine damage from gentamicin.
    • Administration routes included intramuscular, intravenous, and dialysate.

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  • Caloric tests were performed to assess vestibular function.

    • Main Results:

    • No patients developed severe vertigo; instead, they reported vertical visual bouncing upon ambulation.
    • This oscillopsia worsened with activity (running, bumpy roads) and ceased with stillness.
    • Caloric testing confirmed bilateral non-functioning labyrinths.
    • Symptoms gradually improved over several months.
    • No evidence of cochleotoxicity (hearing damage) was observed.

    Conclusions:

    • Gentamicin-induced severe labyrinthine damage can manifest as oscillopsia rather than vertigo.
    • The symptom is associated with bilateral vestibular deafferentation.
    • The visual disturbance shows a pattern of improvement over time.
    • Careful monitoring for ototoxic effects is crucial in patients receiving gentamicin, especially those with renal impairment.