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A cloned cell line mediating natural killer cell function inhibits immunoglobulin secretion
The Journal of Experimental Medicine
|August 1, 1982
Summary
Natural killer (NK) cells can suppress immunoglobulin (Ig) secretion from activated B lymphocytes. This NK cell activity may regulate antibody production by targeting B cells, independent of H-2 locus identity.
Area of Science:
- Immunology
- Cell Biology
- Cancer Research
Background:
- A unique cloned cell line with natural killer (NK) cell-like functions was previously established.
- This cell line lyses conventional targets and also lipopolysaccharide-activated B lymphocytes.
Purpose of the Study:
- To investigate whether NK-like cells can inhibit B cell function, specifically immunoglobulin (Ig) secretion.
- To determine the potential role of NK cells in regulating B cell antibody production.
Main Methods:
- Testing the ability of NK-like clones to suppress Ig secretion in vitro and in vivo.
- Assessing the minimal cell concentration required for inhibition.
Main Results:
- NK-like clones suppressed Ig secretion at very low cell concentrations (0.2% of total population).
- Inhibition of Ig secretion did not require H-2 locus identity between effector and target cells.
Conclusions:
- NK cells may recognize non-major histocompatibility complex (MHC) products on activated B lymphocytes.
- NK cell-mediated lysis of B cells could be a fundamental mechanism regulating antibody secretion.