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Increased mortality in the siblings and offspring of Pi type MS and MZ men from Saskatchewan. Mortality and Pi type
Abstract:
alpha 1-Antitrypsin phenotypes were determined in 1,395 male Saskatchewan grain buyers. These included 1,254 type M, 80 MS, 35 MZ and 26 which were untyped or other rare phenotypes. Sibling and offspring of the MS men had a significantly greater number of deaths (p less than 0.01). Offspring of MZ men also had an increased number of deaths. These appeared to occur in all age except in those 2-17 years of age. This finding raises questions about the role of both the S and Z alleles.
Insights
Alpha 1-Antitrypsin (AAT) S and Z alleles are linked to increased mortality in offspring. This study examined AAT phenotypes in Saskatchewan grain buyers and their families, revealing significant death rate increases.
Area of Science:
- Genetics
- Epidemiology
- Pulmonology
Background:
- Alpha 1-Antitrypsin (AAT) deficiency is an inherited condition.
- Specific AAT alleles, like S and Z, are associated with increased health risks.
Purpose of the Study:
- To investigate the association between alpha 1-Antitrypsin (AAT) phenotypes and mortality rates.
- To examine the impact of specific AAT alleles (S and Z) on familial mortality.
Main Methods:
- Phenotyping of alpha 1-Antitrypsin (AAT) in 1,395 male grain buyers.
- Statistical analysis of mortality data in siblings and offspring of individuals with different AAT phenotypes.
Main Results:
- A significantly higher number of deaths were observed in siblings and offspring of men with the MS phenotype (p < 0.01).
- Offspring of men with the MZ phenotype also showed an increased number of deaths.
- Increased mortality was noted across all age groups, except for the 2-17 year olds.
Conclusions:
- The findings suggest a potential role for both the S and Z alpha 1-Antitrypsin (AAT) alleles in contributing to increased familial mortality.
- Further research is warranted to elucidate the specific mechanisms by which these alleles influence survival rates.