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Adverse reactions to trimethoprim-sulfamethoxazole in hospitalized patients
Reviews of Infectious Diseases
|March 1, 1982
Abstract:
Of 1,121 hospitalized recipients of trimethoprim-sulfamethoxazole, 91 (8%) experienced reactions that were attributed to this drug. The most common adverse effects were gastrointestinal upset (3.9%) and skin reactions (3.3%). Serious toxicity attributable to the drug was rare.
Insights
Trimethoprim-sulfamethoxazole caused adverse reactions in 8% of hospitalized patients. Most reactions were mild gastrointestinal or skin issues, with serious toxicity being rare.
Area of Science:
- Pharmacology
- Clinical Medicine
- Drug Safety
Background:
- Trimethoprim-sulfamethoxazole is a widely prescribed antibiotic.
- Understanding its adverse event profile is crucial for patient safety.
Purpose of the Study:
- To determine the incidence and types of adverse reactions associated with trimethoprim-sulfamethoxazole in hospitalized patients.
Main Methods:
- Retrospective analysis of 1,121 hospitalized patients receiving trimethoprim-sulfamethoxazole.
- Documentation and categorization of reported adverse drug reactions.
Main Results:
- 8% (91 out of 1,121) of patients experienced drug-attributed adverse reactions.
- The most frequent adverse effects included gastrointestinal upset (3.9%) and skin reactions (3.3%).
- Serious toxicity was infrequently observed.
Conclusions:
- Trimethoprim-sulfamethoxazole is generally well-tolerated in hospitalized patients.
- Monitoring for common gastrointestinal and skin reactions is advisable.
- The drug appears to have a favorable safety profile regarding severe toxicity.