Related Experiment Videos
Target cells for malignant catarrhal fever virus in rabbits
Veterinary Research Communications
|May 1, 1982
Summary
Researchers identified the primary cells targeted by malignant catarrhal fever virus (MCFV) in rabbits. Lymphocytes from infected rabbits showed the most MCFV infectivity, indicating they are the main host cells for this herpesvirus.
Area of Science:
- Veterinary Virology
- Immunology
- Cell Biology
Background:
- Malignant catarrhal fever virus (MCFV) is a significant pathogen in susceptible livestock.
- Understanding the cellular tropism of MCFV is crucial for disease management and control.
Purpose of the Study:
- To determine the primary target cells of MCFV in experimentally infected rabbits.
- To investigate the infectivity of MCFV within different immune cell populations.
Main Methods:
- Lymphocytes and macrophages/monocytes were isolated from the lymph nodes and spleens of MCFV-infected rabbits.
- Cellular infectivity was assessed using secondary calf thyroid cell monolayers.
Main Results:
- Lymphocytes from infected rabbits demonstrated the highest MCFV infectivity.
- Macrophages/monocytes also exhibited some level of MCFV infectivity.
Conclusions:
- Lymphocytes are identified as the major target cells for MCFV in rabbits.
- This finding contributes to understanding the pathogenesis of malignant catarrhal fever.