Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Maturation of normal primate white matter: computed tomographic correlation

R M Quencer

    AJR. American Journal of Roentgenology
    |September 1, 1982
    PubMed
    Summary

    This study tracked white matter maturation in infant baboons using computed tomography (CT). Normal maturation occurs in two phases, crucial for identifying potential neonatal brain injury.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Current Applications of MRI-Guided Laser Interstitial Thermal Therapy in the Treatment of Brain Neoplasms and Epilepsy: A Radiologic and Neurosurgical Overview.

    AJNR. American journal of neuroradiology·2015
    Same author

    The "thickened" ligamentum flavum: is it buckling or enlargement?

    AJNR. American journal of neuroradiology·2010
    Same author

    Quantitative analysis of the effects of physiologic brain motion on point-resolved spectroscopy.

    AJNR. American journal of neuroradiology·2006
    Same author

    [Progress in understanding spinal cord injuries. Clinical aspects, imaging, pathological correlations].

    Der Radiologe·2002
    Same author

    Thirty-ninth annual meeting of the American Society of Neuroradiology.

    AJNR. American journal of neuroradiology·2001
    Same author

    Cervical myelopathy: imaging/clinical correlations and the application of evolving magnetic resonance imaging techniques in cervical spinal cord abnormalities.

    Spine·2001

    Area of Science:

    • Neuroscience
    • Radiology
    • Developmental Biology

    Background:

    • Understanding normal brain development is essential for diagnosing neurological disorders in infants.
    • Computed tomography (CT) is a valuable tool for assessing brain structure.
    • White matter maturation is a key indicator of neurological health in early life.

    Purpose of the Study:

    • To determine the rate and degree of normal white matter maturation in infant baboons.
    • To establish reference data for white matter development in key brain regions.
    • To correlate imaging findings with gross and histologic specimens.

    Main Methods:

    • Five infant baboons underwent computed tomography (CT) scans during their first year.
    • CT numbers were analyzed to quantify white matter maturation.
    • Results were correlated with gross and histologic examination of brain tissue.

    Main Results:

    • Two distinct phases of white matter maturation were identified: a rapid phase (0-12 weeks) and a gradual phase (after 12 weeks).
    • Frontal white matter, initially the least mature, reached parity with other regions by 4 weeks.
    • CT values increased with age, reflecting ongoing myelination and maturation.

    Conclusions:

    • Normal white matter maturation follows a predictable biphasic pattern.
    • Deviations from this normal maturation rate, particularly in periventricular regions, may indicate neonatal hypoxia/ischemia.
    • This knowledge aids in the prognostic assessment of white matter damage in neonates.

    Related Experiment Videos