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Pregnancy and Nelson's syndrome. Two case reports

J G Feeney, G A Craig, K W Hancock

    British Journal of Obstetrics and Gynaecology
    |September 1, 1978
    PubMed
    Summary

    Two patients with Nelson's syndrome experienced normal pregnancies and spontaneous deliveries. One patient developed temporary diabetes insipidus during pregnancy, which resolved post-delivery.

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    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Pituitary Disorders

    Background:

    • Nelson's syndrome is a rare condition that can occur after bilateral adrenalectomy for Cushing's syndrome.
    • It is characterized by rapid enlargement of a pituitary adenoma and associated clinical manifestations.
    • Pregnancy in women with pituitary disorders requires careful management.

    Observation:

    • This report details two cases of pregnant women diagnosed with Nelson's syndrome.
    • One patient presented with a pituitary basophil adenoma.
    • This patient experienced the onset of diabetes insipidus in the third trimester of pregnancy.

    Findings:

    • Both patients with Nelson's syndrome had successful pregnancies culminating in normal spontaneous deliveries.
    • The diabetes insipidus observed in one patient resolved spontaneously postpartum.
    • This suggests that pregnancy may not be contraindicated in carefully selected patients with Nelson's syndrome.

    Implications:

    • These findings indicate that pregnancy can be managed safely in women with Nelson's syndrome.
    • The cases highlight the potential for pituitary adenomas to manifest or change during pregnancy.
    • Further research is warranted to understand the long-term impact of pregnancy on pituitary adenoma behavior in Nelson's syndrome.

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