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Pregnancy and Nelson's syndrome. Two case reports
British Journal of Obstetrics and Gynaecology
|September 1, 1978
Summary
Two patients with Nelson's syndrome experienced normal pregnancies and spontaneous deliveries. One patient developed temporary diabetes insipidus during pregnancy, which resolved post-delivery.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Pituitary Disorders
Background:
- Nelson's syndrome is a rare condition that can occur after bilateral adrenalectomy for Cushing's syndrome.
- It is characterized by rapid enlargement of a pituitary adenoma and associated clinical manifestations.
- Pregnancy in women with pituitary disorders requires careful management.
Observation:
- This report details two cases of pregnant women diagnosed with Nelson's syndrome.
- One patient presented with a pituitary basophil adenoma.
- This patient experienced the onset of diabetes insipidus in the third trimester of pregnancy.
Findings:
- Both patients with Nelson's syndrome had successful pregnancies culminating in normal spontaneous deliveries.
- The diabetes insipidus observed in one patient resolved spontaneously postpartum.
- This suggests that pregnancy may not be contraindicated in carefully selected patients with Nelson's syndrome.
Implications:
- These findings indicate that pregnancy can be managed safely in women with Nelson's syndrome.
- The cases highlight the potential for pituitary adenomas to manifest or change during pregnancy.
- Further research is warranted to understand the long-term impact of pregnancy on pituitary adenoma behavior in Nelson's syndrome.