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[Acute liver failure--therapeutic aspects 1982]

G Brunner

    Fortschritte Der Medizin
    |July 22, 1982
    PubMed
    Summary

    Fulminant hepatic failure, a rare but severe liver condition, has a high mortality rate. Early intervention with intensive care and specific invasive therapies like baboon liver perfusion or plasma exchange may offer benefits.

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    Area of Science:

    • Hepatology
    • Critical Care Medicine
    • Transplantation

    Background:

    • Fulminant hepatic failure (FHF) is a rare clinical syndrome.
    • It affects approximately 400 individuals annually in Germany.
    • Causes include viral hepatitis, toxic hepatitis, and liver hypoxia.

    Purpose of the Study:

    • To summarize the epidemiology and treatment of fulminant hepatic failure.
    • To highlight the critical need for early therapeutic intervention.
    • To evaluate the efficacy of various treatment modalities.

    Main Methods:

    • Review of existing literature on fulminant hepatic failure.
    • Analysis of epidemiological data from the Federal Republic of Germany.
    • Assessment of therapeutic outcomes for conservative and invasive measures.

    Main Results:

    • Fulminant hepatic failure exhibits an 80-90% mortality rate.
    • Early initiation of therapy is crucial for patient outcomes.
    • Invasive therapies such as baboon liver perfusion and plasma exchange show potential benefit when applied early.

    Conclusions:

    • Fulminant hepatic failure requires prompt and aggressive management.
    • Intensive conservative care forms the cornerstone of treatment.
    • Specific early-stage invasive interventions warrant consideration in treatment protocols.

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