Cyclosporin-A inhibits accumulation of lymphocytes within lymph nodes

The ability of cyclosporin-A (CS-A) to modify lymphocyte accumulation, seen in lymph nodes draining a site of antigen deposition, has been compared with the effect of other drugs known to affect lymphocytes and/or macrophages. CS-A markedly inhibited lymphocyte accumulation in a dose-related manner, whereas aspirin, BW755c (3 amino 1 [m (trifluoromethyl) phenyl] 2-pyrazoline) and hydrocortisone were without effect. Indomethacin produced inconclusive results. The time of CS-A administration was critical, the drug needing to be present before antigen inoculation, being ineffective if given 23 hr after antigen.