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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 15, 2010

Radiographic patterns of opportunistic lung infections and Kaposi sarcoma in homosexual men

D I McCauley, D P Naidich, B S Leitman

    AJR. American Journal of Roentgenology
    |October 1, 1982
    PubMed

    Insights

    This study identified four radiographic patterns in patients with opportunistic lung infections and Kaposi sarcoma. Early diagnosis and rebiopsy are crucial for identifying co-infections and Kaposi sarcoma.

    Area of Science:

    • Pulmonology
    • Infectious Diseases
    • Oncology

    Background:

    • Patients with opportunistic infections and Kaposi sarcoma often present with complex lung involvement.
    • Distinguishing between Pneumocystis carinii pneumonia and other opportunistic infections, as well as Kaposi sarcoma, is clinically challenging.

    Purpose of the Study:

    • To describe the distinct radiographic patterns associated with Pneumocystis carinii pneumonia, other opportunistic infections, and Kaposi sarcoma in the lungs.
    • To evaluate the utility of rebiopsy in identifying additional or changing pathologies during treatment.

    Main Methods:

    • Retrospective analysis of 30 patients with lung involvement from December 1980 to March 1982.
    • Identification and categorization of four distinct radiographic patterns.
    • Correlation of radiographic findings with specific pathogens and Kaposi sarcoma presence.
    • Rebiopsy performed in cases of disease progression during therapy.

    Main Results:

    • Pneumocystis carinii pneumonia presented as a symmetric, homogeneous perihilar pneumonia progressing to diffuse consolidation.
    • Asymmetric/focal infiltrates suggested concomitant opportunistic infections, predominantly fungal.
    • Nodular/linear densities with adenopathy indicated lung parenchymal Kaposi sarcoma without concurrent pneumonia.
    • A mixed pattern was observed in patients with multiple infections and Kaposi sarcoma.
    • Rebiopsy identified other infections or Kaposi sarcoma in 50% of cases with disease progression.

    Conclusions:

    • Distinct radiographic patterns can help differentiate between Pneumocystis carinii pneumonia, other opportunistic infections, and Kaposi sarcoma in the lungs.
    • Rebiopsy is valuable for detecting evolving or co-existing conditions, guiding treatment adjustments.
    • Multifaceted lung involvement is common in immunocompromised patients, necessitating comprehensive diagnostic approaches.

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