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Related Experiment Videos

[Shock-treatment in gastro-intestinal-bleeding with 3,5% isocyanate crosslinked polypeptide solution]

H Stadler, G Höllerl, K H Tscheliessnigg

    Der Anaesthesist
    |July 1, 1982
    PubMed
    Summary

    Haemaccel (3.5% isocyanate crosslinked polypeptide solution) effectively increased intravascular volume in patients with gastro-intestinal bleeding. This study found no undesirable side effects, indicating its safety for shock treatment and prophylaxis.

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    Area of Science:

    • Biomedical Engineering
    • Pharmacology
    • Critical Care Medicine

    Context:

    • Gastro-intestinal bleeding is a common cause of hypovolemic shock.
    • Effective volume replacement is crucial for managing shock and preventing complications.
    • Haemaccel, a polypeptide solution, is used for volume expansion.

    Purpose:

    • To evaluate the efficacy and safety of Haemaccel (3.5% isocyanate crosslinked polypeptide solution) in patients with gastro-intestinal bleeding.
    • To assess Haemaccel's ability to increase intravascular volume for shock treatment and prophylaxis.
    • To monitor for any adverse events associated with Haemaccel administration.

    Summary:

    • A prospective study administered 500 ml of Haemaccel (3.5% isocyanate crosslinked polypeptide solution) to patients experiencing gastro-intestinal bleeding.

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  • The infusions successfully increased intravascular volume, meeting therapeutic goals for shock management.
  • No adverse effects, including anaphylaxis, anaphylactoid reactions, coagulopathy, or oliguria, were observed during the study.

    • Impact:

    • Haemaccel demonstrates a favorable safety profile and efficacy in managing hypovolemic shock secondary to gastro-intestinal bleeding.
    • The findings support the use of Haemaccel as a reliable option for volume resuscitation in this patient population.
    • This study contributes to the understanding of Haemaccel's clinical utility in critical care settings.