[Effect of polymethylene- and polyhydroxyethylene-bis-(2-amino-1,3-diazepinium) iodides on cell and model membranes]

The effect of polymethylene- and polyoxyethylene-bis-(2-amino-1, 3-diazepinium) iodides on the membranes of neuromuscular synapsis and mitochondria as on the artificial membranes was studied. The compounds examined were shown to change the amplitude and kinetics of postsynaptic membrane responses to acetylcholine. Inhibition of end plate potentials and oxidative phosphorylation of mitochondria with different derivatives of diazepinium correlated with changes in the surface potential of the artificial phospholipid membrane. It is concluded that the derivatives of diazepinium directly interact with ionic channels of the acetylcholine-activated postsynaptic membrane.