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Interobserver variability in interpreting contrast left ventriculograms (CASS)

L F Wexler, J Lesperance, T J Ryan

    Catheterization and Cardiovascular Diagnosis
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Quality control centers reread left ventricular cineangiograms from a multicenter study. Results showed good agreement for volume and ejection fraction calculations, and regional wall motion analysis, ensuring reliable data for coronary artery disease research.

    Area of Science:

    • Cardiology
    • Medical Imaging
    • Quality Control in Clinical Trials

    Background:

    • Multicenter studies require rigorous quality control for accurate data.
    • Left ventricular cineangiography is crucial for assessing cardiac function in coronary artery disease (CAD).
    • Variability in image analysis can impact study outcomes.

    Purpose of the Study:

    • To evaluate the reliability of left ventricular (LV) volume and ejection fraction (EF) measurements.
    • To assess the consistency of regional LV wall motion abnormality analysis.
    • To validate data quality from clinical sites against a central quality control (QC) center.

    Main Methods:

    • Randomly selected LV cineangiograms from the Coronary Artery Surgery Study (CASS) were recalled and reread by a QC center.

    Related Experiment Videos

  • End diastolic volume (EDV), end systolic volume (ESV), and EF were calculated and compared.
  • Regional LV wall motion was assessed in RAO and LAO views, with segments graded for abnormality severity.

    • Main Results:

    • High correlation coefficients were observed for EDV (0.71), ESV (0.84), and EF (0.79) between clinical sites and QC.
    • Interobserver differences for regional wall motion abnormalities were low (7% RAO, 10% LAO) after excluding minor discrepancies.
    • Overall agreement for total LV scores, reflecting wall motion severity, showed a strong correlation (0.83).

    Conclusions:

    • Centralized quality control of left ventricular cineangiograms ensures reliable measurements of LV volumes, EF, and regional wall motion.
    • The established QC procedures provide confidence in the data used for the CASS multicenter study.
    • Standardized analysis protocols are effective in minimizing interobserver variability in cardiac imaging assessments.