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Failure to detect immunologic stigmata in schizophrenia
The sera of 17 patients with acute or chronic schizophrenia were tested for antibodies to a human brain extract or to Molt cells; a human T-cell line, with negative results. The level of in vivo lymphocyte stimulation was investigated by determination of the proportion of peripheral blood lymphocytes in the G1, S or G2 + M phases of the cell cycle and by their uptake of 3H-thymidine. There was no sign of increased lymphocyte mitotic activity by these two tests. Therefore, immunologic stigmata could not be detected by these methods in these schizophrenic patients.
The sera of 17 patients with acute or chronic schizophrenia were tested for antibodies to a human brain extract or to Molt cells; a human T-cell line, with negative results. The level of in vivo lymphocyte stimulation was investigated by determination of the proportion of peripheral blood lymphocytes in the G1, S or G2 + M phases of the cell cycle and by their uptake of 3H-thymidine. There was no sign of increased lymphocyte mitotic activity by these two tests. Therefore, immunologic stigmata could not be detected by these methods in these schizophrenic patients.