Experimental lens-induced granulomatous endophthalmitis in common laboratory animals

Guinea pigs and mice after immunization with lens proteins were observed to develop a typical form of experimental phacoanaphylactic endophthalmitis after lens injury. Sensitization to lens protein elicited a good antibody response in rabbits, however no disease developed after lens injury. This is another example of frequent discrepancies between autoimmune responses and autoimmune disease and indicates the importance of investigating mechanisms of phlogogenicity in autoimmune disease.