[GLA-protein of bone. Physiologic factor and new biological marker in bone pathology]

The gamma-carboxyglutamic acid-containing protein (GLA-protein) present in bone has strong affinity for hydroxyapatite crystals and its synthesis is vitamin D-dependent, which suggests that it might play a major role in bone physiology. It is also the first sensitive and specific marker of bone tissue remodelling. Usefulness of GLA-protein determinations in the diagnosis and therapeutic monitoring of bone diseases remains to be demonstrated by further studies.