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Conjunctival spheroid degeneration. Recurrence after excision

M S Norn

    Acta Ophthalmologica
    |June 1, 1982
    PubMed
    Summary
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    Conjunctival biopsy for spheroid degeneration led to a significant reduction in spheroids over 18 months. However, band-shaped keratopathy worsened in the cornea, and pinguecula recurrence was observed in a few cases.

    Area of Science:

    • Ophthalmology
    • Ocular Surface Disease

    Background:

    • Spheroid degeneration is a common condition affecting the conjunctiva.
    • Conjunctival biopsy is a potential treatment option, but its long-term effects on spheroid presence and related ocular conditions are not fully understood.

    Purpose of the Study:

    • To evaluate the effect of conjunctival biopsy on spheroid degeneration.
    • To assess the recurrence of pinguecula and changes in band-shaped keratopathy after biopsy.

    Main Methods:

    • Excision of conjunctiva in 15 eyes (14 subjects) with spheroid degeneration.
    • Observation period of 18 months post-biopsy.
    • Quantification of autofluorescent and colorless spheroids before and after biopsy.
    • Assessment of pinguecula recurrence and corneal changes (band-shaped keratopathy).

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    Main Results:

    • A significant reduction in both autofluorescent (6%) and colorless (13%) spheroids was observed 18 months post-biopsy.
    • Spheroid presence near the biopsy site was minimal, with a slight, non-significant increase in colorless bodies.
    • Band-shaped keratopathy aggravated, with new large, autofluorescent spheroids forming in the cornea.
    • Pinguecula recurrence occurred mildly in 3 out of 13 cases within 18 months.

    Conclusions:

    • Conjunctival biopsy effectively reduces spheroid degeneration in the short to medium term.
    • Biopsy may not prevent the progression of band-shaped keratopathy or completely eliminate recurrence risk for pinguecula.
    • Further research is needed to understand the long-term implications and optimal management strategies.