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Related Experiment Videos

Circulating immune complexes in eosinophilic fasciitis

J R Seibold, G P Rodnan, T A Medsger

    Arthritis and Rheumatism
    |October 1, 1982
    PubMed
    Summary
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    Serum immune complexes, measured via Raji cell assay, are frequently elevated in active eosinophilic fasciitis. These findings suggest immune complex levels correlate with disease activity more than other markers.

    Area of Science:

    • Immunology
    • Rheumatology
    • Dermatology

    Background:

    • Eosinophilic fasciitis is an inflammatory connective tissue disease.
    • The role of immune complexes in eosinophilic fasciitis pathogenesis is not fully understood.

    Purpose of the Study:

    • To measure serum immune complex levels in patients with eosinophilic fasciitis.
    • To assess the correlation between immune complex levels and disease activity.

    Main Methods:

    • Serum immune complexes were quantified using three methods: Raji cell radioimmunoassay, agarose gel electrophoresis, and C1q agglutination-inhibition.
    • Patients included 22 with eosinophilic fasciitis, with serial measurements in 8.

    Main Results:

    • Elevated immune complexes were detected by Raji cell assay in 64% of patients, by agarose gel electrophoresis in 59%, and by C1q agglutination-inhibition in 41%.

    Related Experiment Videos

  • Raji cell assay showed significantly higher levels during active disease (77%) compared to inactive disease (8%) (P < 0.0005).
  • Immune complex levels correlated better with disease activity than eosinophilia, hypergammaglobulinemia, or elevated erythrocyte sedimentation rate.

    • Conclusions:

    • Serum immune complexes, particularly when measured by Raji cell assay, are frequently elevated in eosinophilic fasciitis.
    • Elevated immune complexes are associated with active disease and may serve as a valuable biomarker for disease activity in eosinophilic fasciitis.