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Cerebral atrophy. An immunological disorder?

B D Janković, S Jakulić, J Horvat

    Lancet (London, England)
    |July 30, 1977
    PubMed
    Summary

    Delayed skin sensitivity reactions to brain proteins were more frequent in patients with cerebral atrophy. This suggests a link between cerebral atrophy and the body's immune system response, specifically cell-mediated immunity.

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    Area of Science:

    • Neuroimmunology
    • Cellular Immunology

    Background:

    • Cerebral atrophy, a loss of brain tissue, can have various causes.
    • The role of the immune system in neurological conditions is an area of ongoing research.

    Purpose of the Study:

    • To investigate potential immune system involvement in cerebral atrophy of unknown origin.
    • To explore the relationship between cell-mediated immunity and cerebral atrophy.

    Main Methods:

    • Skin testing was performed on patients with cerebral atrophy, schizophrenia/neurosis, and healthy controls.
    • Human brain and liver proteins were used as antigens for delayed hypersensitivity skin tests.

    Main Results:

    • A significantly higher frequency of positive delayed skin-sensitivity reactions to brain proteins was observed in the cerebral atrophy group.
    • No significant difference in reactions to liver proteins was noted across groups.

    Conclusions:

    • The findings suggest a correlation between cerebral atrophy and altered cell-mediated immunity.
    • Immune responses to brain antigens may play a role in the pathogenesis of cerebral atrophy.

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