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Related Experiment Videos

Effect of triac on the developing heart

E G Olsen, C Symons, C Hawkey

    Lancet (London, England)
    |July 30, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Triac exposure during pregnancy caused heart muscle changes in offspring, resembling hypertrophic cardiomyopathy. Thyroid function may be relevant in unexplained heart conditions.

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    Area of Science:

    • Cardiology
    • Endocrinology
    • Developmental Biology

    Background:

    • Thyroid hormones play a crucial role in cardiac development and function.
    • Thyroid hormone analogs, like Triac, can influence cardiovascular parameters.
    • Understanding the impact of maternal exposure to thyroid-related compounds on fetal cardiac development is essential.

    Purpose of the Study:

    • To investigate the morphological and ultrastructural effects of maternal Triac administration on the hearts of rat offspring.
    • To assess potential links between Triac exposure and cardiac abnormalities resembling human cardiomyopathies.

    Main Methods:

    • Pregnant rats were administered varying doses of Triac (diethanolamine salt of triiodothyroacetic acid) via intramuscular injection.
    • Offspring hearts were examined using both histological and ultrastructural methods.

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  • A control group and three dose-varying Triac groups were analyzed.

    • Main Results:

    • Histological examination revealed only mild cardiac hypertrophy in offspring.
    • Ultrastructural analysis showed disarray of myocardial fibrils in offspring from the highest Triac dose group.
    • These ultrastructural changes were similar to those seen in human hypertrophic cardiomyopathy.

    Conclusions:

    • Maternal exposure to high doses of Triac can induce cardiac ultrastructural changes in offspring.
    • The findings suggest a potential role for thyroid function assessment in cases of obscure cardiac disease.
    • Further research into the developmental cardiotoxicity of thyroid hormone analogs is warranted.