The frequency of mutant-specific killer precursors in related and unrelated mouse strains

The frequency of mutant-specific cytotoxic T lymphocyte precursors (CTL-P) has been analyzed in several mouse strains. While H-2 antigens of responder strains have a limited influence on the frequency of major H antigen-specific CTL-P, the frequency of mutant-specific CTL-P can be equally as high in unrelated and related strains. In general, the frequency does not reflect the closeness of kinship between stimulator and responder.