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Water and hermal diffusivity in a lipid-water smectic phase

W K Chan, P S Pershan

Biophysical Journal

|September 1, 1978

Summary

Light scattering measured water diffusion in phospholipid systems. Diffusion coefficients were determined, revealing insights into water

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Area of Science:

Physical chemistry
Materials science
Biophysics

Background:

Phospholipid systems form multilamellar structures crucial for biological membranes.
Understanding water dynamics within these structures is key to membrane function.
Previous methods lacked precision in measuring water relaxation dynamics.

Purpose of the Study:

To apply light scattering for the first time to measure hydrodynamic relaxation of water concentration inhomogeneities.
To quantify diffusion coefficients and activation energy for water within phospholipid multilayers.
To develop a model relating diffusion to chemical potential and free water zones.

Main Methods:

Utilized a novel version of forced Rayleigh scattering, enhancing signal detection via scattered light phase information.
Measured diffusion coefficients parallel to the lamellae in dipalmitoyl phosphatidyl choline-water systems.
Analyzed relaxation rates to determine diffusion coefficients across varying temperatures and water concentrations.

Main Results:

Diffusion coefficients for water parallel to lamellae ranged from 8 x 10(-7) to 2 x 10(-5) cm2/s.
A model successfully linked diffusion coefficients to water chemical potential and a 'free water zone' thickness.
Deduced free water zone thickness agreed with X-ray diffraction estimates.
Activation energy decreased with increasing water concentration.
Thermal diffusivity was found to be approximately 10(-3) cm2/s.

Conclusions:

Light scattering provides a precise method for studying water dynamics in phospholipid multilayers.
The 'free water zone' model offers valuable insights into water behavior within these systems.
Findings contribute to understanding water's role in biological membranes and related materials.

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