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Related Experiment Videos

Reactive arthritis associated with Campylobacter enteritis

U B Schaad

    Pediatric Infectious Disease
    |September 1, 1982
    PubMed
    Summary

    Campylobacter jejuni infections can lead to reactive arthritis, a condition rarely diagnosed with Campylobacter enteritis. This study reviews 21 cases, highlighting typical symptoms and excellent prognosis for this gastrointestinal-related joint inflammation.

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    Area of Science:

    • Gastroenterology
    • Rheumatology
    • Immunology

    Background:

    • Campylobacter jejuni is a significant cause of bacterial diarrhea.
    • Reactive arthritis following intestinal infections is well-documented but rarely linked to Campylobacter enteritis.
    • Understanding this association is crucial for accurate diagnosis and management.

    Observation:

    • A review of 21 patients with Campylobacter-reactive arthritis was conducted.
    • The interval between diarrhea and arthritis varied from days to weeks.
    • Joint involvement was typically sterile, migratory, and affected large joints in most patients.

    Findings:

    • Fever and leukocytosis were uncommon, but elevated erythrocyte sedimentation rate was observed.
    • A strong association (approximately 60%) was found with the HLA-B27 genetic marker.
    • The condition is self-limiting, with joint symptoms resolving within weeks to months.

    Implications:

    • Campylobacter-reactive arthritis shares features with reactive arthritis from other enteric pathogens like Salmonella, Shigella, and Yersinia.
    • Recognition of this association can improve diagnostic accuracy for patients presenting with post-infectious arthritis.
    • The excellent prognosis suggests conservative management is often sufficient for Campylobacter-induced reactive arthritis.

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